S173. Evaluation of a Potent and Selective PET Radioligand to Image COX-1 in Human and Nonhuman Primates

Cyclooxygenase (COX)-1 is generally considered a constitutive enzyme that serves a role in normal function, but studies have demonstrated that it also contributes to proinflammatory responses, particularly in brain. Developing in vivo COX-1 activity measurements would permit definitive studies in healthy and inflammatory conditions. Towards this end, our laboratory recently developed 11C-PS13, a potent and selective PET radioligand for COX-1. This study sought to determine whether 11C-PS13 can selectively image constitutive levels of COX-1 in human and nonhuman primates.