Diethylphosphoryl-OxymaB (DEPO-B) as a Solid Coupling Reagent for Amide Bond Formation

Fernando Albericio,Ashish Kumar,Yahya E. Jad, Ayman El-Faham,Beatriz G. de la Torre

LETTERS IN ORGANIC CHEMISTRY（2019）

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摘要

A new phosphonium based coupling reagent DEPO B has been synthesized from 5-(hydroxyimino)-1,3-dimethylpyrimidine-2,4,6 (1H,3H,5H)-trione (Oxyma B) and diethyl chlorophosphate in presence of base. It is a solid material and the hydrolytic stability and solubility was evaluated for confirming its capability for usage in automated peptide synthesizer.

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关键词

Coupling reagent,phosphonium salts,diethylphosphoryl-OxymaB,hydrolytic stability,solubility

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