An integrated modelling methodology for estimating the prevalence of centronuclear myopathy

•There is a lack of comprehensive data on CNM prevalence by age and disease subtype.•There is a need for an integrated model enhancing current epidemiologic data.•The CNM incidence can be stratified by causative gene, severity and geographic region.•The CNM prevalence is estimated by causative gene, severity and geographic region.•The current data provide insight into CNM outcomes, e.g. severity and life years lost.