De novo Gene Signature Identification from Single-Cell RNA-Seq with Hierarchical Poisson Factorization
bioRxiv, pp. 367003-22, 2018.
Common approaches to gene signature discovery in single cell RNA-sequencing (scRNA-seq) depend upon predefined structures like clusters or pseudo-temporal order, require prior normalization, or do not account for the sparsity of single cell data. We present single cell Hierarchical Poisson Factorization (scHPF), a Bayesian factorization ...More
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