The hygiene hypothesis: immunological mechanisms of airway tolerance
Current Opinion in Immunology（2018）
摘要
•Microbial and environmental signals set tonic activation status of barrier tissues.•Signaling from barrier tissues licenses dendritic cells to induce T helper 2 cells.•Pulmonary immune system in early-life prone to asthma development.•Mechanistic understanding needed to translate epidemiological findings in therapies.
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