Hibiscus sabdariffa polyphenol-enriched extract inhibits colon carcinoma metastasis associating with FAK and CD44/c-MET signaling

•Roselle flower polyphenols suppressed motility of colon cancer cell DLD-1.•Roselle flower polyphenols inhibited focal adhesion kinase (FAK), CD44/c-MET and the associated signaling.•Roselle flower polyphenols in vivo lowered p-FAK, CD44, and c-MET.•Roselle flower polyphenols in vivo inhibited liver metastasis of DLD-1 cell.