Cell wall inhibitors increase the accumulation of rifampicin in Mycobacterium tuberculosis
Access microbiology(2019)
摘要
There is a need for new combination regimens for tuberculosis. Identifying synergistic drug combinations can avoid toxic side effects and reduce treatment times. Using a fluorescent rifampicin conjugate, we demonstrated that synergy between cell wall inhibitors and rifampicin was associated with increased accumulation of rifampicin. Increased accumulation was also associated with increased cellular permeability.
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关键词
Mycobacterium tuberculosis,mycobacteria,permeability,rifampicin,tuberculosis
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