Glycemic Control with Fast-Acting Insulin Aspart According to Dose Adjustment Method in Type 1 Diabetes: A Post Hoc Analysis of Onset 8

Insulin dosing based on carbohydrate counting (CC) is the gold standard for improving glycemic control in type 1 diabetes (T1D). It has been suggested that for patients with T1D using CC, fast-acting insulin aspart (FA) may offer improved glycemic control vs. insulin aspart (IAsp). This post hoc analysis of Onset 8, a 26-week, treat-to-target trial, further assessed the impact of dose adjustment methodology (DAM) on the efficacy and safety of mealtime FA and IAsp, each with insulin degludec. Subjects with previous experience continued CC, while remaining subjects used a simple bolus algorithm.