Clinical Impact Of Left Ventricular Trabeculae In Hypertrophic Cardiomyopathy: Insights From Cardiac Magnetic Resonance Analysis

Introduction: Hypertrabeculation has been associated with adverse events in patients with left ventricular (LV) non-compaction. However, the clinical significance remains unclear in patients with other cardiomyopathies. Hypothesis: LV trabeculae analyzed by cardiac magnetic resonance (CMR) may have a pathophysiological significance and clinical impact in patients with HCM. Methods: 102 HCM patients receiving regular outpatient treatment underwent CMR. LV volume and mass were analyzed from short-axis cine images using a steady-state free precession sequence and LV fibrosis mass were obtained from late gadolinium enhancement imaging. Individual trabeculae and papillary muscles (TPM) and papillary muscles (PM) were manually planimetered separately on each end-diastolic frame in every slice. Trabeculae (T) was calculated by subtraction of PM from TPM. The data were compared with those of 22 normal control subjects (Cont). Results: In total HCM patients, LV mass index (compacted muscle excluding TPM) was 83.5 ...