Biotin-guided anticancer drug delivery with acidity-triggered drug release

CHEMICAL COMMUNICATIONS, pp. 9343-9345, 2015.

Cited by: 19|Bibtex|Views0|DOI:https://doi.org/10.1039/c5cc03003j
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Other Links: pubmed.ncbi.nlm.nih.gov|academic.microsoft.com

Abstract:

A novel biotin-guided anticancer drug delivery system, prodrug 9, consisting of biotin, nitrobenzene, and doxorubicin, with acid-triggered drug releasing capability was synthesized. Its cellular uptake and anticancer activity are selective to the HepG2 cell line over the WI-38 cell line, as revealed by fluorescence confocal microscopic ex...More

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