Comparison of the PRNT and an immune fluorescence assay in yellow fever vaccinees receiving immunosuppressive medication.

•The 17 D Yellow Fever vaccination yields an effective immune response in immune-compromised patients.•In measuring post vaccination seroprotection, the sensitivity of the Plaque Reduction Neutralization Test (PRNT) is superior to the Indirect Fluorescence Assay (IFA).•A negative post-vaccination IFA does not rule out seroprotection against Yellow Fever.•The patient sample is far too small to draw any conclusions on the issue safety, regarding Yellow Fever vaccination in immune-compromised patients.