Long term follow up of the EORTC 18952 trial of adjuvant therapy in resected stage IIB-III cutaneous melanoma patients comparing intermediate doses of interferon-alpha-2b (IFN) with observation: Ulceration of primary is key determinant for IFN-sensitivity.

Eggermont Alexander M M,Suciu Stefan,Rutkowski Piotr, Kruit Willem H,Punt Cornelis J,Dummer Reinhard,Salès François,Keilholz Ulrich,de Schaetzen Gaetan,Testori Alessandro, Null Null

European Journal of Cancer（2016）

引用 83|浏览9

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摘要

•The 25-month interferon (IFN) schedule yielded to better outcome than the observation group.•Ulceration of the primary is a strong predictive factor for IFN-alpha sensitivity.•Stage IIB–IIIN1 patients with an ulcerated primary had the highest treatment benefit.

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关键词

Melanoma,Adjuvant,Interferon,Ulceration,Predictive factors,Randomised trial

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