Lipodystrophy and severe metabolic dysfunction in mice with adipose tissue-specific insulin receptor ablation.

Guifen Qiang, Hyerim Whang Kong,Shanshan Xu, Hoai An Pham,Sebastian D Parlee,Aaron A Burr,Victoria Gil,Jingbo Pang,Amy Hughes,Xuejiang Gu,Giamila Fantuzzi,Ormond A MacDougald,Chong Wee Liew

Molecular Metabolism（2016）

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摘要

•Adipoq-Cre-mediated IR KO leads to lipodystrophy in mice.•IR KO differentially affects white, brown and marrow fat development and metabolism.•IR KO affects marrow adipocytes lipid accumulation but not development.•Insulin signaling is required for UCP1 expression.

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关键词

Insulin signaling,White adipose tissue,Lipodystrophy,Marrow adipose tissue,Brown adipose tissue

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