Aldehyde dehydrogenase 2 deficiency blunts compensatory cardiac hypertrophy through modulating Akt phosphorylation early after transverse aorta constriction in mice

Guang Xia,Fan Fan,Ming Liu,Shijun Wang,Jian Wu,Cheng Shen,Shasha Han,Cong Wang,Jianguo Jia,Yunzeng Zou,Kai Hu,Junbo Ge,Aijun Sun

Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease（2016）

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摘要

•ALDH2 deficiency blunts compensatory cardiac hypertrophy early after transverse aorta constriction(TAC).•ALDH2 deficiency attenuates compensatory cardiac hypertrophy through regulating Akt phosphorylation and expression.•ALDH2 could affect PTEN expression in transverse aorta constriction mice.

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关键词

ALDH2,Compensatory cardiac hypertrophy,Transverse aorta constriction,PI3K,Akt,PTEN

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