Effects of fluoride on insulin signaling and bone metabolism in ovariectomized rats.

Amanda Gomes Pereira,Fernando Yamamoto Chiba,Maria Sara de Lima Coutinho Mattera,Renato Felipe Pereira,Rita de Cássia Alves Nunes,Thaís Verônica Saori Tsosura,Roberta Okamoto,Doris Hissako Sumida

Journal of Trace Elements in Medicine and Biology（2017）

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摘要

•Chronic treatment with NaF promoted insulin resistance and decreased insulin signal.•NaF treatment caused changes in bone metabolism markers in ovariectomized (OVX) rats.•NaF treatment promoted decreased trabecular bone area of the tibia in OVX rats.•NaF treatment promoted increased plasma levels of insulin, OCN and TNF-α in OVX rats.•Data suggest the need for caution in the use of NaF for the treatment of osteoporosis.

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关键词

Fluoride,Insulin resistance,Osteoporosis,Bone loss

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