The Role of GluN2A in Cerebral Ischemia: Promoting Neuron Death and Survival in the Early Stage and Thereafter

Molecular Neurobiology, pp. 1208-1216, 2018.

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Keywords:
GluN2A Cerebral ischemia Ca2+ overload C-terminal signaling

Abstract:

Over-activation of NMDA receptors is a crucial step required for brain damage following a stroke. Although clinical trials for NMDA receptor blockers have failed, the role of GluN2A subunit in cerebral ischemia has been extensively evaluated in recent years. However, the effect of GluN2A on neuron damage induced by cerebral ischemia remai...More

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