The response of Escherichia coli to the alkylating agents chloroacetaldehyde and styrene oxide.

Mark M Muenter,Ariel Aiken,Jadesola O Akanji, Samir Baig,Sirine Bellou,Alyssa Carlson,Charles Conway, Courtney M Cowell,Nicholas A DeLateur, Alexis Hester,Christopher Joshi,Caitlin Kramer,Becky S Leifer,Emma Nash, Macee H Qi,Meghan Travers, Kelly C Wong,Man Hu,Na Gou,Roger W Giese,April Z Gu,Penny J Beuning

Mutation Research/Genetic Toxicology and Environmental Mutagenesis（2019）

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摘要

•Numerous stress responses are induced by chloroacetaldehyde and styrene oxide.•DNA damage is most prominent category of stress responses.•Strains lacking recA, ruvA, and ybfE are sensitive to chloroacetaldehyde.•Strains lacking recA, mutM, nfo, uvrA, uvrD, ybfE are sensitive to styrene oxide.

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关键词

Transcriptional reporters,DNA repair,DNA damage,SOS response

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