Inhibition Of Nhe1 Induced Apoptosis In Cytarabine Resistant Leukemia Cell Lines And Primary Leukemia Cells From Aml Patients, Which Showed Increased Intracellular Ph And Nhe1 Activity

Background: Na/H exchanger 1 (NHE1), an important participant in the precise regulation system of intracellular pH (pHi), is known to be involved in pathological processes such as cell transformation, maintenance and active progression of the neoplastic process. Some studies have showed that leukemic cells showed higher pHi than normal cells, and NHE1 inhibitor could induce acidification and apoptosis of the leukemic cells. In this study, we tried to elucidate the role of NHE1 in leukemic cells according to cytarabine (AraC) resistance.