Pharmacokinetics of sulfamethoxazole and trimethoprim in Pacific white shrimp, Litopenaeus vannamei, after oral administration of single-dose and multiple-dose.
Environmental Toxicology and Pharmacology(2017)
摘要
•SMZ and TMP present different kinetic characteristics.•In single-dose administration, SMZ elimination is slower than TMP.•In multi-dose administration, SMZ reached steady state level, while TMP didn’t.•SMZ was more widely distributed in the tissues than TMP.
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关键词
Sulfamethoxazole and trimethoprim,Pharmacokinetics,Single-dose and multiple-dose,Pacific white shrimp,Tissue distribution
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