Membrane curvature regulates ligand-specific membrane sorting of GPCRs in living cells

Kadla R Rosholm,Natascha Leijnse,Anna Mantsiou,Vadym Tkach,Søren L Pedersen,Volker F Wirth,Lene B Oddershede,Knud J Jensen,Karen L Martinez,Nikos S Hatzakis,Poul Martin Bendix,Andrew Callan-Jones,Dimitrios Stamou

NATURE CHEMICAL BIOLOGY（2017）

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摘要

Membrane curvature induces sorting of GPCRs within live-cell-membrane protrusions, and the curvature-dependent sorting is affected by agonist binding. Thermodynamic modeling suggests that this is due to an energetic drive to match receptor shape and elasticity to membrane curvature.

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关键词

Biophysics,G protein-coupled receptors,Membrane trafficking,Chemistry/Food Science,general,Biochemical Engineering,Biochemistry,Cell Biology,Bioorganic Chemistry

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