Rif1 maintains telomeres and mediates DNA repair by encasing DNA ends

Stefano Mattarocci,Julia K Reinert,Richard D Bunker,Gabriele A Fontana,Tianlai Shi,Dominique Klein,Simone Cavadini,Mahamadou Faty,Maksym Shyian,Lukas Hafner,David Shore,Nicolas H Thomä,Ulrich Rass

NATURE STRUCTURAL & MOLECULAR BIOLOGY（2017）

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摘要

Structure determination and functional analyses of budding yeast Rif1 reveal a novel, hooked N-terminal DNA-binding domain required for telomere maintenance and checkpoint control and show that Rif1's role in DNA-repair pathway choice is conserved in yeast and mammalian cells.

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关键词

DNA-binding proteins,Double-strand DNA breaks,Non-homologous-end joining,Telomeres,X-ray crystallography,Life Sciences,general,Biochemistry,Protein Structure,Membrane Biology,Biological Microscopy

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