Binary Nanoparticle-graphene Hybrid Structure-based Highly Sensitive Biosensing Platform for Norovirus-like Particle Detection.
ACS applied materials & interfaces(2017)
摘要
Nanoparticle-decorated carbon nanotubes or graphenes have attracted attention because their properties, such as electrical, magnetio-optical and plasmon resonance energy transfer, exhibit synergistic effects. These hybrid carbon nanomaterials are widely used in sensing platforms to monitor target biomolecules, gases, and chemicals. In this study, binary nanoparticles, specifically gold (Au)/magnetic nanoparticle (MNP)-decorated graphenes (GRPs), were applied in a virus-sensing platform. This hybrid material exhibited multiple functionalities, including magnetic, plasmonic and enhanced electrical properties. Au/MNP-GRPs were synthesized in 2 steps at room temperature under mild conditions and magnetically deposited on a Pt-interdigitated electrode (IDE) as electrical-sensing channels. After deposition onto the electrode, the surface of Au/MNP-GRPs was conjugated with norovirus antibody (Ab) to produce a norovirus-like particle (NoV-LP)-sensing platform. NoV-LPs were successfully detected by the hybrid nanomaterial-sensing platform, exhibiting high sensitivity and specificity in a concentration range from 0.01 pg to 1 ng. In this case, the limit of detection was calculated as 1.16 pg/ml. Thus, binary-nanoparticle-decorated graphene shows excellent potential as an electrical-sensing platform for biomolecules.
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关键词
binary nanoparticle-decorated graphene,Au/MNP-decorated graphene,Norovirus-like particle,electrical biosensor,magnetically deposited sensing channel
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