Obesity and type 2 diabetes, not a diet high in fat, sucrose, and cholesterol, negatively impacts bone outcomes in the hyperphagic Otsuka Long Evans Tokushima fatty rat.

Laura C Ortinau,Melissa A Linden,Rebecca Dirkes,R Scott Rector,Pamela S Hinton

Bone（2017）

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摘要

•Hyperphagic OLETF rats developed obesity and diabetes with no effect of the high-fat, sucrose, cholesterol diet•Obese/T2D OLETF rats had lower P1NP and greater CTx and sclerostin than non-obese, non-diabetic controls•Trabecular bone volume and microarchitecture were adversely affected by obesity/T2D, independent of diet.

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关键词

AGE,BMC,BMD,BV/TV,Conn.D,Ct.Ar,Ct.Th.,CTx,DA,DXA,EF,G,Imax,Imin,J,Ks,Le,LETO,Ma.Ar,OC,OLETF,P1NP,PBS,Su,T2D,Tb.N,Tb.Sp,Tb.Th,Tmax,TRAP5b,Tt.Ar,U,μCT

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