Piezos thrive under pressure: mechanically activated ion channels in health and disease
NATURE REVIEWS MOLECULAR CELL BIOLOGY(2017)
摘要
Cellular mechanotransduction, the process of translating mechanical forces into biological signals, is crucial for a wide range of physiological processes. A role for ion channels in sensing mechanical forces has been proposed for decades, but their identity in mammals remained largely elusive until the discovery of Piezos. Recent research on Piezos has underscored their importance in somatosensation (touch perception, proprioception and pulmonary respiration), red blood cell volume regulation, vascular physiology and various human genetic disorders.
更多查看译文
关键词
Membrane biophysics
AI 理解论文
溯源树
样例
生成溯源树,研究论文发展脉络