Molecular Imaging of Apoptosis in Ischemia Reperfusion Injury With Radiolabeled Duramycin Targeting Phosphatidylethanolamine: Effective Target Uptake and Reduced Nontarget Organ Radiation Burden.

Hideki Kawai,Farhan Chaudhry,Aditya Shekhar,Artiom Petrov,Takehiro Nakahara,Takashi Tanimoto,Dongbin Kim,Jiqiu Chen,Djamel Lebeche,Francis G Blankenberg,Koon Y Pak,Frank D Kolodgie,Renu Virmani,Partho Sengupta,Navneet Narula,Roger J Hajjar,Harry W Strauss,Jagat Narula

JACC: Cardiovascular Imaging（2018）

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摘要

Duramycin is similarly effective in imaging apoptotic cell death as Annexin-V with lower nontarget organ radiation. Clinical feasibility of apoptosis imaging with a PE-seeking tracer should be tested.

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关键词

cell death,myocardial infarction,necroptosis,necrosis,radionuclide imaging,reperfusion injury

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