Efficacy of artemisinin-based combination therapies and prevalence of molecular markers associated with artemisinin, piperaquine and sulfadoxine-pyrimethamine resistance in Sierra Leone.

•The evaluated artemisinin combination therapies were highly efficacious for the treatment of uncomplicated malaria.•Pfk13 mutations and Pfplasmepsin2 multiple copies, associated with artemisinin and piperaquine resistance, respectively, were absent.•The very low prevalence of the quintuple mutant detected supports the introduction of intermittent preventive treatment for infants with SP.•The efficacy and molecular markers of the recommended artemisinins and partners drugs should be monitored continuously.