Intranasally administered polyethylenimine adjuvanted influenza M2 ectodomain induces partial protection against H9N2 influenza A virus infection in chickens.

Irshad Ahmed Hajam,Jehyoung Kim,John Hwa Lee

Veterinary Immunology and Immunopathology（2019）

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摘要

•Intranasally coadministered polyethylenimine (PEI) and H9N2 M2e induces humoral and cell-mediated immunity in chickens.•PEI adjuvanted M2e antigen induces CD4+ T cell and IFN-gamma responses in chickens.•PEI adjuvanted M2e antigen reduces fecal viral shedding in chickens post-H9N2 challenge.

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关键词

M2e,H9N2 influenza A virus,Chickens,Vaccine,Polyethyleneimine adjuvant

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