Genome-wide association studies identify susceptibility loci for epithelial ovarian cancer in east Asian women.

Gynecologic Oncology（2019）

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摘要

•This study analyzed genotyping data from >7,000 individuals of Asian descent to find risk loci for epithelial ovarian cancer•We identified two novel genome-wide significant loci, plus evidence of association at an additional 28 regions•eQTL analyses in 404 TCGA tumors highlight ESPNL as a novel susceptibility gene for ovarian cancer

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关键词

Genome-wide association study,Asian ancestry,Epithelial ovarian cancer,Enhancer,eQTL,Gene regulation

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