Interleukin-6 Contributes to the Development of Anemia in Juvenile CKD.

Oleh Akchurin,Edwin Patino,Vidhi Dalal,Kelly Meza,Divya Bhatia, Simon Brovender,Yuan-Shan Zhu,Susanna Cunningham-Rundles,Eduardo Perelstein,Juhi Kumar,Stefano Rivella,Mary E Choi

Kidney International Reports（2019）

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摘要

IL-6 contributes to development of anemia in juvenile CKD, through mechanisms that include induction of hypoferremia, aggravation of renal fibrosis, and alteration of the erythropoietin axis. IL-6 appears to be a promising therapeutic target in the management of CKD-anemia.

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关键词

anemia,chronic kidney disease,erythropoietin,inflammation,pediatric nephrology

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