RNA Splicing of the BHC80 Gene Contributes to Neuroendocrine Prostate Cancer Progression.

Yinan Li,Ning Xie,Ruiqi Chen,Ahn R Lee,Jessica Lovnicki,Emma A Morrison,Ladan Fazli,Qingfu Zhang,Catherine A Musselman,Yuzhuo Wang,Jiaoti Huang,Martin E Gleave,Colin Collins,Xuesen Dong

European Urology（2019）

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摘要

We report that alternative RNA splicing of the histone demethylase BHC80 gene promotes prostate adenocarcinoma progression to treatment-induced neuroendocrine prostate cancer (t-NEPC). Functionally, reprogrammed RNA splice variant of BHC80-2 mediates nonepigenetic actions in cytoplasm, to stimulate multiple tumor-promoting cytokines for t-NEPC development androgen independently.

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关键词

Treatment-induced neuroendocrine prostate cancer,Alternative RNA splicing,BHC80,SRRM4

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