Probing transient non-native states in amyloid beta fiber elongation by NMR.

Jeffrey R Brender,Anirban Ghosh,Samuel A Kotler,Janarthanan Krishnamoorthy,Swapna Bera,Vanessa Morris,Timir Baran Sil,Kanchan Garai,Bernd Reif,Anirban Bhunia,Ayyalusamy Ramamoorthy

CHEMICAL COMMUNICATIONS（2019）

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摘要

Using NMR to probe transient binding of A(1-40) monomers to fibers, we find partially bound conformations with the highest degree of interaction near F19-K28 and a lesser degree of interaction near the C-terminus (L34-G37). This represents a shift away from the KLVFFA recognition sequence (residues 16-21) currently used for inhibitor design.

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