Efficient weapon for protracted warfare to malaria: A chondroitin sulfate derivates-containing injectable, ultra-long-lasting meshy-gel system.

•A novel material (octadecylamine modified chondroitin sulfate) was synthesized.•A new long acting meshy gel system was prepared.•Detailed and in-depth evaluations about the gel system have been made in vitro and in vivo.•Great potential for the gel to reduce and interrupt malaria transmission.