Harpagide inhibits neuronal apoptosis and promotes axonal regeneration after spinal cord injury in rats by activating the Wnt/β-catenin signaling pathway.

•Harpagide inhibits neuronal apoptosis and promotes axonal regeneration after spinal cord injury.•Harpagide attenuated neuronal apoptosis via activation of the Wnt/β-catenin signaling pathway.•Harpagide may be a promising drug for the treatment of SCI.