Oral and systemic HPV antibody kinetics post-vaccination among HIV-positive and HIV-negative men.

Duration and functional aspects of the oral and systemic antibody responses following HPV vaccination in HIV-negative (HIV−) and HIV-positive (HIV+) men are not well characterized. Oral and systemic HPV-16 and HPV-18-specific antibody levels were evaluated over 18-months of follow-up, in HIV+ and HIV− men. Sera and oral gargles from 147 HIV− men, ages 27–45 and 75 HIV+ men, ages 22–61, who received 3-doses of quadrivalent HPV vaccine were tested for HPV-16 and HPV-18 antibodies at Day 1, Month 7 (1 month post-dose 3), and Month 18 (12 months post-dose 3) and HPV avidity (Day 1, and Month 7) using L1-VLP ELISA.