In Situ In Vivo radiolabeling of polymer-coated hydroxyapatite nanoparticles to track their biodistribution in mice.

Volodymyr Lobaz,Rafał Konefał,Jiří Pánek,Martin Vlk,Ján Kozempel,Miloš Petřík,Zbyněk Novy,Soňa Gurská, Pawel Znojek,Petr Štěpánek,Martin Hrubý

Colloids and Surfaces B: Biointerfaces（2019）

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摘要

•HAP NPs were colloidally stabilized with tailored hydrophilic polymers.•NPs were nontoxic and suitable for applications in vivo.•NPs were labeled with fluorescent and radioactive bone-seeking agents in vitro.•NPs were labeled with 99mTc-HEDP in vivo one hour after intravenous injection.

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关键词

Bone-seeking agent,Hydroxybisphosphonate,Polyoxazoline,Radiopharmaceutical,Hydroxyapatite nanoparticle

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