Polydatin inhibits proliferation and promotes apoptosis of doxorubicin-resistant osteosarcoma through LncRNA TUG1 mediated suppression of Akt signaling.

•Development of doxorubicin-resistance is the main difficulty for osteosarcoma treatment.•Aberrant upregulation of TUG1 expression was found in doxorubicin-resistant osteosarcoma cells.•Polydatin inhibits the cell proliferation and promotes the apoptosis of doxorubicin-resistant osteosarcoma cells.•TUG1/Akt signaling suppression was essential for Polydatin in treating doxorubicin-resistant osteosarcoma cells.