Expression, Localization and Functional Activity of the Major Na⁺/H⁺ Exchange Isoforms Expressed in the Intestinal Cell Line Caco-2BBe.

Yan Yu,Anna Seidler,Kunyan Zhou,Zhenglin Yuan,Sunil Yeruva,Mahdi Amiri,Chris C Yun,Katerina Nikolovska,Ursula Seidler

Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology（2019）

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摘要

Differentiated Caco-2BBe cells display particularly high mRNA expression levels of NHE2, which can be functionally identified in the apical membrane. Although at low intracellular pH, NHE2 transport rate was far lower than that of NHE1. NHE2 activity was nevertheless essential for the maintenance of the steady-state pH of these cells.

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关键词

Enterocyte,Intestinal electrolyte transport,NBCn1,NHE2,NHE3,NHE8,pHi-regulation

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