Development of Poly(ɛ-caprolactone) Scaffold Loaded with Simvastatin and Beta-Cyclodextrin Modified Hydroxyapatite Inclusion Complex for Bone Tissue Engineering.
POLYMERS(2016)
摘要
In this study, we developed poly(-caprolactone) (PCL) 3D scaffolds using a solid free form fabrication (SFF) technique. -cyclodextrin (CD) was grafted to hydroxyapatite (HAp) and this CD grafted HAp was coated onto the PCL scaffold surface, followed by drug loading through an inclusion complex interaction between the CD and adamantane (AD) or between CD and simvastatin (SIM). The scaffold structure was characterized by scanning electron microscopy (SEM). The release profile of simvastatin in the -CD grafted HAp was also evaluated. Osteogenic differentiation of adipose-derived stromal cells (ADSCs) was examined using an alkaline phosphatase activity (ALP) assay. The results suggest that drug loaded PCL-HAp 3-D scaffolds enhances osteogenic differentiation of ADSCs.
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关键词
-cyclodextrin,hydroxyapatite,poly(-caprolactone) 3-D scaffolds,simvastatin,boneregeneration
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