Exercise-Induced Mitophagy in Skeletal Muscle and Heart.
EXERCISE AND SPORT SCIENCES REVIEWS(2019)
摘要
Regular exercise enhances mitochondrial function by promoting healthy mitochondrial remodeling, but the underlying mechanisms are not thoroughly understood. An emerging hypothesis suggests that, in addition to anabolic events such as mitochondria biogenesis, the selective degradation of dysfunctional mitochondria (i.e., mitophagy) also is a key component of exercise-mediated adaptations in striated muscle, which eventually leads to better mitochondrial functions.
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关键词
mitophagy,mitochondrial reticulum,exercise,skeletal muscle,cardiomyocyte
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