Restoration of cytosolic calcium inhibits Mycobacterium tuberculosis intracellular growth: theoretical evidence and experimental observation.

•Model studied to capture mechanisms by which Mtb suppress phagosome-lysosome fusion.•Some plausible methods are identified to restore PI3P oscillations which is necessary for phagosome maturation and killing of Mtb.•RyR2 agonist caffeine inhibits growth of intracellular Mtb in macrophages validation to our model result.