Induction of innate cytokine responses by respiratory mucosal challenge with R848 in zebrafish, mice and humans.

Fränze Progatzky,Akhilesh Jha,Madina Wane,Ryan S Thwaites,Spyridon Makris,Robin J Shattock,Cecilia Johansson,Peter J Openshaw,Laurence Bugeon,Trevor T Hansel,Margaret J Dallman

Journal of Allergy and Clinical Immunology（2019）

引用 10|浏览26

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摘要

We compared live zebrafish, mouse and human nasal challenge responses to the TLR7/8 agonist resiquimod (R848). We found remarkably similar induction of mediators in the three species, offering novel mucosal models of innate anti-viral immunity.

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关键词

comparative cross-species analysis,mucosal innate immunity,nasal respiratory mucosa,resiquimod,vaccine adjuvants

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