Xylo-C-nucleosides with a pyrrolo[2,1-f][1,2,4]triazin-4-amine heterocyclic base: Synthesis and antiproliferative properties.

Peng Nie,Elisabetta Groaz,Dirk Daelemans,Piet Herdewijn

Bioorganic & Medicinal Chemistry Letters（2019）

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摘要

•The first examples of a new series of antitumor nucleoside analogues are described.•C-nucleosides with a xylose sugar ring were synthesized and characterized.•Compound 7 displayed a micromolar antiproliferative activity.

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关键词

Nucleoside analogues,C-nucleosides,Xylo-nucleosides,Antitumor agents

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