Ferrocenylchalcone–uracil conjugates: synthesis and cytotoxic evaluation

Huisgen’s azide–alkyne cycloaddition reaction was employed to synthesize a series of 1 H -1,2,3-triazole-tethered uracil–ferrocenyl chalcone conjugates with the aim of evaluating their in vitro anti-proliferative efficacy on human leukemia (CCRF-CEM) and human breast adenocarcinoma (MDA-MB-468) cell lines. Cytotoxic evaluation studies identified a number of synthesized conjugates that inhibited the proliferation of leukemia cancer cells by ~70% after 72 h. The selected synthesized conjugates were found to be significantly less cytotoxic against normal kidney cell line (LLC-PK1) when compared with CCRF-CEM cancer cells. Synthesis and in vitro anti-proliferative efficacy of 1 H -1,2,3-triazole-tethered uracil–ferrocenylchalcone conjugates on human leukemia (CCRF-CEM) and human breast adenocarcinoma (MDA-MB-468) cell lines.