Effects of cooking oil fume derived fine particulate matter on blood vessel formation through the VEGF/VEGFR2/MEK1/2/ERK1/2/mTOR pathway in human umbilical vein endothelial cells.

Furong Zhu,Han Cheng,Ruoqian Lei,Chaowei Shen,Jie Liu,Lijuan Hou,Chao Zhang,Yachun Xu,Rui Ding,Jiyu Cao

Environmental Toxicology and Pharmacology（2019）

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摘要

•COF-derived PM2.5 inhibited the tube formation of HUVECs in a concentration- dependent manner.•VEGF, VEGFR2, MEK1/2, ERK1/2 and mTOR pathway was involved in the inhibitory effects.•Cell viability gradually decreased after exposure to COF-derived PM2.5.

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关键词

Cooking oil fume,PM2.5,Angiopoiesis,Human umbilical vein endothelial cells,Vascular endothelial growth factor,Low birth weight

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