FOXA1 + regulatory T cells: A novel T cell subset that suppresses antitumor immunity in lung cancer.

Jinyan Liang,Chen Tian,Yulan Zeng,Qifan Yang,Yangyang Liu,Yuting Liu,Jingjing Wu,Yue Hu,Feifei Gu,Kai Zhang,Yan Wang,Yong Zhang,Li Liu

Biochemical and Biophysical Research Communications（2019）

引用 12|浏览42

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摘要

•FOXA1+ Tregs are elevated in lung cancer.•PD-L1+ Tregs expressed high level of FOXA1 but low level of FOXP3.•FOXA1+ Tregs exhibited more suppressive functionality in vitro and in vivo.

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关键词

Lung cancer,Regulatory T cells,FOXA1,Treatment response

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