Effects of Post-Mastectomy Radiation Therapy on Immediate Tissue Expander and Acellular Dermal Matrix Reconstruction: Results of a Prospective Clinical Trial.

To the best of our knowledge, this is the first dedicated prospective trial evaluating long-term cosmetic and complication outcomes among patients treated with immediate TE-ADM reconstruction followed by PMRT. Most patients (65.4%) met the success criteria in this prospective single-arm series. The great majority (93.5%) achieved final reconstruction; most with good-to-excellent overall cosmetic outcomes (79.2%). The results with longer follow-up will be of interest and further investigation of strategies to optimize reconstruction with PMRT are warranted.