Smooth muscle-specific Gsα deletion exaggerates angiotensin II-induced abdominal aortic aneurysm formation in mice in vivo.

•Smooth muscle phenotype switch involves in the development of AAA (abdominal aortic aneurysm).•Gsα deficiency induced the smooth muscle phenotype switch via the HuR/KLF4 pathway.•Smooth muscle-specific Gsα deletion exaggerated AngII-induced AAA formation.•Gsα expression was significantly reduced in the mouse and human AAA samples.