Injectable, long-acting PLGA formulations: Analyzing PLGA and understanding microparticle formation

Sarah Skidmore
Sarah Skidmore
Justin Hadar
Justin Hadar
John Garner
John Garner
Haesun Park
Haesun Park
Bong Kwan Soh
Bong Kwan Soh
Gwangheum Yoon
Gwangheum Yoon
Dijia Yu
Dijia Yu
Xiaohui Jiang
Xiaohui Jiang

Journal of Controlled Release, pp. 125-134, 2019.

Cited by: 0|Views6
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Abstract:

Injectable, long-acting depot formulations based on poly(lactide-co-glycolide) (PLGA) have been used clinically since 1989. Despite 30 years of development, however, there are only 19 different drugs in PLGA formulations approved by the U.S. Food and Drug Administration (FDA). The difficulty in developing depot formulations stems in large...More

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