Association of TP53 mutations with response and longer survival under immune checkpoint inhibitors in advanced non-small-cell lung cancer

Sandra Assoun,Nathalie Theou-Anton,Marina Nguenang,Aurélie Cazes,Claire Danel,Baptiste Abbar,Johan Pluvy,Valérie Gounant,Antoine Khalil, Céline Namour,Solenn Brosseau,Gérard Zalcman

Lung Cancer（2019）

引用 106|浏览29

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摘要

•Frequent smoking-inducedTP53 mutations in NSCLC lead to genetic instability.•Genetic instability could drive sensitivity to immunotherapy via neo-antigens.•TP53 mutations were found to actually drive longer OS upon immunotherapy.

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关键词

Non-small-cell lung cancer,TP53 mutations,Tumor mutational burden,Immune checkpoint inhibitors

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