Picornavirus etiology of acute infections among hospitalized infants.

•Enteroviruses (EV) and parechoviruses (PeV) cause a range of illness, including severe illness in young children.•Of 319 patients aged <1 year, CSF specimens from 13 (4.1%) were positive for EV and from 11 (3.4%) for PeV.•Sequencing revealed a variety of EV types and the predominance of PeV-A3 among the PeV-positive case-patients.•Clinicians should consider EV and PeV infections in infants presenting with febrile illness.